Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response

J. Liu; P. Hoffmann; J. Steinmetzer; S.H.C. Askes; S. Kupfer; H. Görls; S. Gräfe; U. Neugebauer; U.R. Gandra; A. Schiller

doi:10.1016/j.poly.2019.04.031

Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response

J. Liu, P. Hoffmann, J. Steinmetzer, S.H.C. Askes, S. Kupfer, H. Görls, S. Gräfe, U. Neugebauer, U.R. Gandra, A. Schiller

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2019We introduce a colorimetric as well as fluorometric dual response CO-releasing molecule as Mn(I) tricarbonyl complex with a nitrobenzoxadiazole (NBD) fluorophore. DFT and TD-DFT studies corroborate that extended conjugation in the principal ligand frame will help to release CO at low energy radiation. A very low toxicity of NBD-CORM was observed against LX-2 and HepaRG® human cell lines.

Original language	English
Pages (from-to)	175-181
Journal	Polyhedron
Volume	172
DOIs	https://doi.org/10.1016/j.poly.2019.04.031
Publication status	Published - 1 Nov 2019
Externally published	Yes

Funding

U.N. and A.S. are grateful to the German Research Foundation (DFG) for supporting FOR 1738 (grant numbers SCHI 1175/2-2 , NE 1744/3-2 ). A.S. thanks the DFG for a Heisenberg fellowship (grant numbers SCHI 1175/4-1 and SCHI 1175/5-1 ). This work was also supported by a grant from the Federal Ministry of Education and Research (Germany), grant number MF130124 and by funding via the CSCC (grant number 01EO1502 ). All DFT calculations have been performed at the computing center of the Friedrich Schiller University of Jena and the computers of the Theoretical Chemistry group of Jena. We thank Prof. Winfried Plass and Florian Reinhardt for ESR measurements as well as Fatina Siwczak and Marko Gröger for providing differentiated HepaRG® cells. U.N. and A.S. are grateful to the German Research Foundation (DFG) for supporting FOR 1738 (grant numbers SCHI 1175/2-2, NE 1744/3-2). A.S. thanks the DFG for a Heisenberg fellowship (grant numbers SCHI 1175/4-1 and SCHI 1175/5-1). This work was also supported by a grant from the Federal Ministry of Education and Research (Germany), grant number MF130124 and by funding via the CSCC (grant number 01EO1502). All DFT calculations have been performed at the computing center of the Friedrich Schiller University of Jena and the computers of the Theoretical Chemistry group of Jena. We thank Prof. Winfried Plass and Florian Reinhardt for ESR measurements as well as Fatina Siwczak and Marko Gröger for providing differentiated HepaRG® cells.

Funders	Funder number
California Department of Fish and Wildlife	SCHI 1175/5-1, SCHI 1175/4-1
Friedrich-Schiller-Universität Jena
Deutsche Forschungsgemeinschaft	SCHI 1175/2-2, FOR 1738, NE 1744/3-2
Bundesministerium für Bildung und Forschung	MF130124
Center for Sepsis Control and Care	01EO1502

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10.1016/j.poly.2019.04.031

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title = "Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response",

abstract = "{\textcopyright} 2019We introduce a colorimetric as well as fluorometric dual response CO-releasing molecule as Mn(I) tricarbonyl complex with a nitrobenzoxadiazole (NBD) fluorophore. DFT and TD-DFT studies corroborate that extended conjugation in the principal ligand frame will help to release CO at low energy radiation. A very low toxicity of NBD-CORM was observed against LX-2 and HepaRG{\textregistered} human cell lines.",

author = "J. Liu and P. Hoffmann and J. Steinmetzer and S.H.C. Askes and S. Kupfer and H. G{\"o}rls and S. Gr{\"a}fe and U. Neugebauer and U.R. Gandra and A. Schiller",

year = "2019",

month = nov,

day = "1",

doi = "10.1016/j.poly.2019.04.031",

language = "English",

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TY - JOUR

T1 - Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response

AU - Liu, J.

AU - Hoffmann, P.

AU - Steinmetzer, J.

AU - Askes, S.H.C.

AU - Kupfer, S.

AU - Görls, H.

AU - Gräfe, S.

AU - Neugebauer, U.

AU - Gandra, U.R.

AU - Schiller, A.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - © 2019We introduce a colorimetric as well as fluorometric dual response CO-releasing molecule as Mn(I) tricarbonyl complex with a nitrobenzoxadiazole (NBD) fluorophore. DFT and TD-DFT studies corroborate that extended conjugation in the principal ligand frame will help to release CO at low energy radiation. A very low toxicity of NBD-CORM was observed against LX-2 and HepaRG® human cell lines.

AB - © 2019We introduce a colorimetric as well as fluorometric dual response CO-releasing molecule as Mn(I) tricarbonyl complex with a nitrobenzoxadiazole (NBD) fluorophore. DFT and TD-DFT studies corroborate that extended conjugation in the principal ligand frame will help to release CO at low energy radiation. A very low toxicity of NBD-CORM was observed against LX-2 and HepaRG® human cell lines.

U2 - 10.1016/j.poly.2019.04.031

DO - 10.1016/j.poly.2019.04.031

M3 - Article

SN - 0277-5387

VL - 172

SP - 175

EP - 181

JO - Polyhedron

JF - Polyhedron

ER -

Visible light-activated biocompatible photo-CORM for CO-release with colorimetric and fluorometric dual turn-on response

Abstract

Funding

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