Vitamin B6 supplementation in elderly men: effects on mood, memory, performance and mental effort

J.B. Deijen, E.J. van der Beek, J.F. Orlebeke, H. van den Berg

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

This study evaluates the effects of vitamin B-6 supplementation (20 mg pyridoxine HCL daily for 3 months) on mood and performance in 38 self-supporting healthy men, aged between 70-79 years. Effects were compared with 38 controls who received placebo and were matched for age, plasma pyridoxal-5′-phosphate (PLP) concentration and intelligence score. Before and after drug intervention vitamin B-6 status was determined, and mood and performance were measured by means of a computerized testing system. In addition, the phasic pupil response was measured in order to assess mental effort. Positive effects of vitamin B-6 supplementation were only found with respect to memory, especially concerning long-term memory. In view of the finding that mental performance improvement and Δ PLP values were most strongly correlated within an intermediate range of Δ PLP, it is suggested that cognitive effects are primarily associated with a certain range of vitamin B-6 status increment. The general conclusion is that vitamin B-6 supplementation improves storage of information modestly but significantly. © 1992 Springer-Verlag.
Original languageEnglish
Pages (from-to)489-496
JournalPsychopharmacology
DOIs
Publication statusPublished - 1992

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