Vitamin D Status and Depressive Symptoms in Older Adults: A Role for Physical Functioning?

Elisa J. de Koning, Liset E.M. Elstgeest, Hannie C. Comijs, Paul Lips, Judith J.M. Rijnhart, Harm W.J. van Marwijk, Aartjan T.F. Beekman, Marjolein Visser, Brenda W.J.H. Penninx, Natasja M. van Schoor

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objectives: Depressive symptoms and low vitamin D status are common in older persons and may be associated, but findings are inconsistent. This study investigated whether 25-hydroxyvitamin D (25(OH)D) concentrations are associated with depressive symptoms in older adults, both cross-sectionally and longitudinally. We also examined whether physical functioning could explain this relationship, to gain a better understanding of the underlying mechanisms. Methods: Data from two independent prospective cohorts of the Longitudinal Aging Study Amsterdam were used: an older cohort (≥65 years, n = 1282, assessed from 1995–2002) and a younger-old cohort (55–65 years, n = 737, assessed from 2002–2009). Measurements: Depressive symptoms were measured at baseline and after 3 and 6 years with the Center of Epidemiological Studies Depression Scale. Cross-sectional and longitudinal linear regression techniques were used to examine the relationship between 25(OH)D and depressive symptoms. The mediating role of physical functioning was examined in the longitudinal models. Results: Cross-sectionally, associations were not significant after adjustment for confounders. Longitudinally, women in the older cohort with baseline 25(OH)D concentrations up to 75 nmol/L experienced 175 to 24% more depressive symptoms in the following 6 years, compared with women with 25(OH)D concentrations >75 nmol/L. Reduced physical performance partially mediated this relationship. In men and in the younger-old cohort, no significant associations were observed. Conclusions: Older women showed an inverse relationship between 25(OH)D and depressive symptoms over time, which may partially be explained by declining physical functioning. Replication of these findings by future studies is needed.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalAmerican Journal of Geriatric Psychiatry
DOIs
Publication statusE-pub ahead of print - 12 Mar 2018

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Vitamin D
Depression
Longitudinal Studies
Epidemiologic Studies
Linear Models

Keywords

  • cohort study
  • depressive symptoms
  • older persons
  • physical functioning
  • Vitamin D

Cite this

de Koning, Elisa J. ; Elstgeest, Liset E.M. ; Comijs, Hannie C. ; Lips, Paul ; Rijnhart, Judith J.M. ; van Marwijk, Harm W.J. ; Beekman, Aartjan T.F. ; Visser, Marjolein ; Penninx, Brenda W.J.H. ; van Schoor, Natasja M. / Vitamin D Status and Depressive Symptoms in Older Adults : A Role for Physical Functioning?. In: American Journal of Geriatric Psychiatry. 2018 ; pp. 1-13.
@article{502ba0c00e8f4308b18ab01d3ed4e852,
title = "Vitamin D Status and Depressive Symptoms in Older Adults: A Role for Physical Functioning?",
abstract = "Objectives: Depressive symptoms and low vitamin D status are common in older persons and may be associated, but findings are inconsistent. This study investigated whether 25-hydroxyvitamin D (25(OH)D) concentrations are associated with depressive symptoms in older adults, both cross-sectionally and longitudinally. We also examined whether physical functioning could explain this relationship, to gain a better understanding of the underlying mechanisms. Methods: Data from two independent prospective cohorts of the Longitudinal Aging Study Amsterdam were used: an older cohort (≥65 years, n = 1282, assessed from 1995–2002) and a younger-old cohort (55–65 years, n = 737, assessed from 2002–2009). Measurements: Depressive symptoms were measured at baseline and after 3 and 6 years with the Center of Epidemiological Studies Depression Scale. Cross-sectional and longitudinal linear regression techniques were used to examine the relationship between 25(OH)D and depressive symptoms. The mediating role of physical functioning was examined in the longitudinal models. Results: Cross-sectionally, associations were not significant after adjustment for confounders. Longitudinally, women in the older cohort with baseline 25(OH)D concentrations up to 75 nmol/L experienced 175 to 24{\%} more depressive symptoms in the following 6 years, compared with women with 25(OH)D concentrations >75 nmol/L. Reduced physical performance partially mediated this relationship. In men and in the younger-old cohort, no significant associations were observed. Conclusions: Older women showed an inverse relationship between 25(OH)D and depressive symptoms over time, which may partially be explained by declining physical functioning. Replication of these findings by future studies is needed.",
keywords = "cohort study, depressive symptoms, older persons, physical functioning, Vitamin D",
author = "{de Koning}, {Elisa J.} and Elstgeest, {Liset E.M.} and Comijs, {Hannie C.} and Paul Lips and Rijnhart, {Judith J.M.} and {van Marwijk}, {Harm W.J.} and Beekman, {Aartjan T.F.} and Marjolein Visser and Penninx, {Brenda W.J.H.} and {van Schoor}, {Natasja M.}",
year = "2018",
month = "3",
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de Koning, EJ, Elstgeest, LEM, Comijs, HC, Lips, P, Rijnhart, JJM, van Marwijk, HWJ, Beekman, ATF, Visser, M, Penninx, BWJH & van Schoor, NM 2018, 'Vitamin D Status and Depressive Symptoms in Older Adults: A Role for Physical Functioning?' American Journal of Geriatric Psychiatry, pp. 1-13. https://doi.org/10.1016/j.jagp.2018.03.004

Vitamin D Status and Depressive Symptoms in Older Adults : A Role for Physical Functioning? / de Koning, Elisa J.; Elstgeest, Liset E.M.; Comijs, Hannie C.; Lips, Paul; Rijnhart, Judith J.M.; van Marwijk, Harm W.J.; Beekman, Aartjan T.F.; Visser, Marjolein; Penninx, Brenda W.J.H.; van Schoor, Natasja M.

In: American Journal of Geriatric Psychiatry, 12.03.2018, p. 1-13.

Research output: Contribution to JournalArticleAcademicpeer-review

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T1 - Vitamin D Status and Depressive Symptoms in Older Adults

T2 - A Role for Physical Functioning?

AU - de Koning, Elisa J.

AU - Elstgeest, Liset E.M.

AU - Comijs, Hannie C.

AU - Lips, Paul

AU - Rijnhart, Judith J.M.

AU - van Marwijk, Harm W.J.

AU - Beekman, Aartjan T.F.

AU - Visser, Marjolein

AU - Penninx, Brenda W.J.H.

AU - van Schoor, Natasja M.

PY - 2018/3/12

Y1 - 2018/3/12

N2 - Objectives: Depressive symptoms and low vitamin D status are common in older persons and may be associated, but findings are inconsistent. This study investigated whether 25-hydroxyvitamin D (25(OH)D) concentrations are associated with depressive symptoms in older adults, both cross-sectionally and longitudinally. We also examined whether physical functioning could explain this relationship, to gain a better understanding of the underlying mechanisms. Methods: Data from two independent prospective cohorts of the Longitudinal Aging Study Amsterdam were used: an older cohort (≥65 years, n = 1282, assessed from 1995–2002) and a younger-old cohort (55–65 years, n = 737, assessed from 2002–2009). Measurements: Depressive symptoms were measured at baseline and after 3 and 6 years with the Center of Epidemiological Studies Depression Scale. Cross-sectional and longitudinal linear regression techniques were used to examine the relationship between 25(OH)D and depressive symptoms. The mediating role of physical functioning was examined in the longitudinal models. Results: Cross-sectionally, associations were not significant after adjustment for confounders. Longitudinally, women in the older cohort with baseline 25(OH)D concentrations up to 75 nmol/L experienced 175 to 24% more depressive symptoms in the following 6 years, compared with women with 25(OH)D concentrations >75 nmol/L. Reduced physical performance partially mediated this relationship. In men and in the younger-old cohort, no significant associations were observed. Conclusions: Older women showed an inverse relationship between 25(OH)D and depressive symptoms over time, which may partially be explained by declining physical functioning. Replication of these findings by future studies is needed.

AB - Objectives: Depressive symptoms and low vitamin D status are common in older persons and may be associated, but findings are inconsistent. This study investigated whether 25-hydroxyvitamin D (25(OH)D) concentrations are associated with depressive symptoms in older adults, both cross-sectionally and longitudinally. We also examined whether physical functioning could explain this relationship, to gain a better understanding of the underlying mechanisms. Methods: Data from two independent prospective cohorts of the Longitudinal Aging Study Amsterdam were used: an older cohort (≥65 years, n = 1282, assessed from 1995–2002) and a younger-old cohort (55–65 years, n = 737, assessed from 2002–2009). Measurements: Depressive symptoms were measured at baseline and after 3 and 6 years with the Center of Epidemiological Studies Depression Scale. Cross-sectional and longitudinal linear regression techniques were used to examine the relationship between 25(OH)D and depressive symptoms. The mediating role of physical functioning was examined in the longitudinal models. Results: Cross-sectionally, associations were not significant after adjustment for confounders. Longitudinally, women in the older cohort with baseline 25(OH)D concentrations up to 75 nmol/L experienced 175 to 24% more depressive symptoms in the following 6 years, compared with women with 25(OH)D concentrations >75 nmol/L. Reduced physical performance partially mediated this relationship. In men and in the younger-old cohort, no significant associations were observed. Conclusions: Older women showed an inverse relationship between 25(OH)D and depressive symptoms over time, which may partially be explained by declining physical functioning. Replication of these findings by future studies is needed.

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