Vitamin D status predicts physical performance and its decline in older persons

Ilse S Wicherts, Natasja M van Schoor, A Joan P Boeke, Marjolein Visser, Dorly J H Deeg, Jan Smit, Dirk L Knol, Paul Lips

Research output: Contribution to JournalArticleAcademicpeer-review


CONTEXT: Vitamin D deficiency is common among older people and can cause mineralization defects, bone loss, and muscle weakness.

OBJECTIVE: The aim of this study was to investigate the association of serum 25-hydroxyvitamin D (25-OHD) concentration with current physical performance and its decline over 3 yr among elderly.

DESIGN: The study consisted of a cross-sectional and longitudinal design (3-yr follow-up) within the Longitudinal Aging Study Amsterdam.

SETTING: An age- and sex-stratified random sample of the Dutch older population was used.

OTHER PARTICIPANTS: Subjects included 1234 men and women (aged 65 yr and older) for cross-sectional analysis and 979 (79%) persons for longitudinal analysis.

MAIN OUTCOME MEASURE(S): Physical performance (sum score of the walking test, chair stands, and tandem stand) and decline in physical performance were measured.

RESULTS: Serum 25-OHD was associated with physical performance after adjustment for age, gender, chronic diseases, degree of urbanization, body mass index, and alcohol consumption. Compared with individuals with serum 25-OHD levels above 30 ng/ml, physical performance was poorer in participants with serum 25-OHD less than 10 ng/ml [regression coefficient (B) = -1.69; 95% confidence interval (CI) = -2.28; -1.10], and with serum 25-OHD of 10-20 ng/ml (B = -0.46; 95% CI = -0.90; -0.03). After adjustment for confounding variables, participants with 25-OHD less than 10 ng/ml and 25-OHD between 10 and 20 ng/ml had significantly higher odds ratios (OR) for 3-yr decline in physical performance (OR = 2.21; 95% CI = 1.00-4.87; and OR = 2.01; 95% CI = 1.06-3.81), compared with participants with 25-OHD of at least 30 ng/ml. The results were consistent for each individual performance test.

CONCLUSIONS: Serum 25-OHD concentrations below 20 ng/ml are associated with poorer physical performance and a greater decline in physical performance in older men and women. Because almost 50% of the population had serum 25-OHD below 20 ng/ml, public health strategies should be aimed at this group.

Original languageEnglish
Pages (from-to)2058-2065
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
Publication statusPublished - 1 Jun 2007

Bibliographical note

From: The Longitudinal Aging Study Amsterdam


  • Aged
  • Aged, 80 and over
  • Aging
  • Cross-Sectional Studies
  • Female
  • Humans
  • Logistic Models
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Motor Activity
  • Predictive Value of Tests
  • Vitamin D
  • Vitamin D Deficiency
  • Journal Article
  • Research Support, Non-U.S. Gov't


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