Vitamin D supplementation to prevent depression and poor physical function in older adults: Study protocol of the D-Vitaal study, a randomized placebo-controlled clinical trial

E.J. de Koning, N.M. van Schoor, B.W.J.H. Penninx, P.J.M. Elders, A.C. Heijboer, J.H. Smit, P.M. Bet, M.W. van Tulder, M. den Heijer, H.W.J. van Marwijk, P. Lips

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Depressive symptoms and decreased physical functioning are interrelated conditions and common in older persons, causing significant individual and societal burden. Evidence suggests that Vitamin D supplementation may be beneficial for both mental and physical functioning. However, previous randomized controlled trials have yielded inconsistent results and often had suboptimal designs. This study examines the effect of Vitamin D supplementation on both depressive symptoms and physical functioning in a high-risk population of older persons with low Vitamin D status. Methods/design: The D-Vitaal study is a randomized, double-blind, placebo-controlled trial investigating the effects of a daily dose of 1200 IU Vitamin D
Original languageEnglish
Article number151
JournalBMC Geriatrics
Volume15
Issue number1
DOIs
Publication statusPublished - 2015

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