Voltage Regulated Uptake and Release of L-Glutamate from a Molecularly Selective Switch for Physiological Applications

n this paper results are presented on the development of a device demonstrating the uptake and release of L-glutamate in solutions with neutral pH. A device which selectively regulates the concentration of biomolecules, such as the primary neural transmitter L-glutamate, could be useful for many biological and medical applications. In the literature it has been demonstrated that polypyrrole (PPy) is a promising material for the recognition basis of molecularly selective devices [1,2]. In this Study we investigated the feasibility of the PPy based "glutamate switch" for the voltage dependent uptake and release of L-glutamate for physiological applications.