Vti Proteins: Beyond Endolysosomal Trafficking

Javier Emperador-Melero; Ruud F. Toonen; Matthijs Verhage

doi:10.1016/j.neuroscience.2018.11.014

Vti Proteins: Beyond Endolysosomal Trafficking

Javier Emperador-Melero, Ruud F. Toonen, Matthijs Verhage^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Vti proteins are conserved from yeast to humans and regulate intracellular membrane trafficking by providing one specific SNARE domain, the Qb SNARE, to the four helical SNARE bundle that drives membrane fusion. Two mammalian Vti genes, Vti1a and Vti1b are reported to regulate distinct aspects of endolysosomal trafficking and retrograde transport to the Golgi, but have also been implicated in synaptic vesicle secretion. In this review, we summarize the current evidence for the role of Vti proteins in intracellular trafficking in different cells. We propose that, despite some unique aspects, the two mammalian VTI genes have largely redundant functions in neurosecretory cells and recycle molecules required for the sorting of regulated cargo to the Golgi. Defects in this recycling also lead to defects in synaptic transmission and dense core vesicle secretion.

Original language	English
Pages (from-to)	32-40
Number of pages	9
Journal	Neuroscience
Volume	420
Early online date	22 Nov 2018
DOIs	https://doi.org/10.1016/j.neuroscience.2018.11.014
Publication status	Published - 10 Nov 2019

Bibliographical note

Funding

This study makes use of data generated by the DECIPHER community. A full list of centers who contributed to the generation of the data is available from http://decipher.sanger.ac.uk and via email from [email protected].

Funders	Funder number
Seventh Framework Programme	322966

Keywords

dense core vesicle
exocytosis
secretory vesicle
SNARE proteins
vesicle biogenesis

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10.1016/j.neuroscience.2018.11.014

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Vti Proteins: Beyond Endolysosomal Trafficking

Abstract

Bibliographical note

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Keywords

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