What Explains Gray Matter Atrophy in Long-standing Multiple Sclerosis?

M.D. Steenwijk, M. Daams, P.J.W. Pouwels, L.J. Balk, P.K. Tewarie, J. Killestein, B.M.J. Uitdehaag, J.J.G. Geurts, F. Barkhof, H. Vrenken

    Research output: Contribution to JournalArticleAcademicpeer-review


    Purpose: To identify the measures of focal and diffuse white matter (WM) abnormalities that are related to whole-brain, deep, and cortical gray matter (GM) atrophy in long-standing multiple sclerosis (MS). Materials and Methods: The institutional review board approved the study; all subjects gave written informed consent. Magnetic resonance (MR) imaging was performed at 3 T in 208 patients with MS of long-standing duration (disease duration ≥ 10 years) and in 60 healthy control subjects. Normalized GM volume (NGMV), normalized WM volume (NWMV), normalized deep GM volume (NDGMV), cortical thickness, and normalized lesion volume (NLV) were quantified. Tissue integrity of normal-appearing WM (NAWM) and lesions was measured by using diffusion-tensor MR imaging. Multivariate associations between measures of GM atrophy and WM abnormalities were assessed in the patient group by using multiple linear regression. Results: NGMV, NDGMV, and cortical thickness were reduced in patients with MS (all P < .001). The final model for NGMV consisted of NWMV, NLV, and patient age and sex (adjusted R
    Original languageEnglish
    Pages (from-to)832-842
    Issue number3
    Publication statusPublished - 2014


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