Abstract
Objectives: The aim of this systematic review was to establish the adjuvant clinical effect of brushing with a dentifrice containing purported active ingredients as compared to a regular sodium fluoride dentifrice with respect to the inhibition of overnight dental plaque regrowth from studies with human participants. Methods: MEDLINE-PubMed, EMBASE and Cochrane CENTRAL were searched, up to June 2019. The inclusion criteria were controlled clinical trials with participants aged ≥ 18 years in good general health. Studies were included that evaluated the effect of toothbrushing with a dentifrice on the inhibition of overnight dental plaque regrowth when an active ingredient was added to the dentifrice as compared to a common sodium fluoride product. Data were extracted from the eligible studies, the risk of bias was assessed, and a meta-analysis was performed where feasible. Result: Independent screening of 213 unique papers resulted in 10 eligible publications that provided 14 comparisons. Stannous fluoride and triclosan dentifrices were found as the active ingredients. The descriptive analysis indicated that all, but two comparisons demonstrated an additional effect on the active-ingredient dentifrice. The meta-analysis supported and strengthened these findings. It showed that when plaque was scored digitally, a DiffM was −3.15(95% CI [−4.61:-1.69], P <.001, prediction interval [−5.07;-1.24]). When plaque was scored clinically, the difference of means (DiffM) was −0.33(95% CI [−0.49:-0.16], P <.001, prediction interval [−0.87; 0.21]). Conclusion: The results of this review demonstrate moderate-quality evidence that brushing with an active-ingredient dentifrice with stannous fluoride or triclosan does provide an added clinically relevant effect concerning plaque inhibition capabilities that surpass the effect of a regular sodium fluoride dentifrice.
| Original language | English |
|---|---|
| Pages (from-to) | 128-141 |
| Number of pages | 14 |
| Journal | International Journal of Dental Hygiene |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 May 2020 |
Funding
The authors gratefully acknowledge the support of Joost Bouwman, the head librarian of the ACTA, Franc van der Vlugt, the head librarian of the KNMT mediacentrum and Stephen M. Siegel, who helped retrieve full‐text papers. We thank the authors Dr J. C. Jakobsen and Dr Lifeng Lin for additional information and the anonymous reviewers for their time and valuable comments. The authors are also grateful to the following authors for their responses, time and effort in searching for additional data: Dr T. He and Dr FS Panagakos. Work for this paper is funded by the regular academic appointment of Van der Weijden and Slot. They and their research team at ACTA have previously received either external advisor fees, lecturer fees, or research grants from toothbrush and dentifrice manufacturers. Those manufacturers included Colgate, Dentaid, GABA, Lactona, Oral-B, Procter & Gamble, Sara Lee, Sunstar and Unilever. The authors gratefully acknowledge the support of Joost Bouwman, the head librarian of the ACTA, Franc van der Vlugt, the head librarian of the KNMT mediacentrum and Stephen M. Siegel, who helped retrieve full-text papers. We thank the authors Dr J. C. Jakobsen and Dr Lifeng Lin for additional information and the anonymous reviewers for their time and valuable comments. The authors are also grateful to the following authors for their responses, time and effort in searching for additional data: Dr T. He and Dr FS Panagakos.
| Funders | Funder number |
|---|---|
| Franc van der Vlugt | |
| Joost Bouwman | |
| KNMT | |
| Procter & Gamble, Sara Lee, Sunstar and Unilever | |
| Alliance for California Traditional Arts |
