Which precocial rodent species is more suitable as the experimental model of microgravity influence on prenatal musculosketal development on international space station?

Slobodan Sekulic*, Aleksandar Jovanovic, Zeljko Zivanovic, Svetlana Simic, Srdjan Kesic, Branka Petkovic, Ivan Capo, Jack JWA van Loon

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

The International Space Station (ISS) has the possibility to perform experiments regarding rodent reproduction in microgravity. The musculoskeletal system at birth in precocial rodent species more resembles the human than that of altricial rodent species. For precocial rodent species with body weight ≤ 500 g (limit of ISS) determined were: adult body mass, newborn body mass, head-body length, tail length, existing variants (wild, domesticated, laboratory), single/group housing, dry food consumption/24 h, water intake/24 h, basal metabolic rate mlO2/g/h, environmental temperature, sand baths, urine output ml/24 h, fecal output g/24 h, size of fecal droplet, hair length, life span, length of oestrus cycle, duration of pregnancy, building nest, litter size, stage of musculoskeletal maturity at birth, and the duration of weaning. Characteristics were obtained by searching SCOPUS as well as the World Wide Web with key words for each of the species in English, Latin and, local language name. These characteristics were compared in order to find most appropriate species. Twelve precocial rodent species were identified. There is not enough data for Common yellow-toothed cavy, and Eastern spiny mouse. Inappropriate species were: Gundis, Dassie rat are a more demanding species for appropriate tending, litter size is small; Octodon degus requires sand baths as well as a nest during the first two weeks after delivery; muscle maturity of Spiny mouse at birth (myotubular stage), does not correspond to the human (late histochemical stage); Chinchilla requires separately housing, daily sand baths, has upper limit of weight. Possibility of keeping Southern mountain cavy as pet animal, short estrus, large litter size, absence of the need for nest and sand baths, makes this species the most promising candidates for experiments on ISS. If an experiment is planned with exposing gravid animals before term of the birth, then they might be kept together in the existing Rodent Habitat (USA). If an experiment with birth in microgravity is planned on ISS, the existing habitats do not provide conditions for such an experiment. It is necessary to develop habitats for separate keeping of pregnant animals to enable the following: 1. undisturbed delivery 2. prevent the possibility of hurting the newborns 3. ensure adequate post-partum maternal care and nursing.

Original languageEnglish
Pages (from-to)48-57
Number of pages10
JournalLife Sciences in Space Research
Volume33
Early online date8 Apr 2022
DOIs
Publication statusPublished - May 2022

Bibliographical note

Funding Information:
The authors thank Sandra Honigs Curator from Zoo Dusseldorf, Germany for data about husbandry of Ctenodactylus gundi and Professor Fracisco Bozinovic from Deaprtmento de Ecologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile for collecting data about Octodon degus. Photos on Image 1. are published thanks to: Mus musculus/J. N. Stuart/www.flickr.com https://creativecommons.org/licenses/by-nc-nd/2.0/; Ratus norvegicus/SASASTRO/ www.flickr.com https://creativecommons.org/licenses/by/2.0/; Acomys dimidiatus/Klaus Rudlof/kdrudloff@web.de/ http://www.biolib.cz; Galea musteloides/Klaus Rudlof/kdrudloff@web.de/ http://www.biolib.cz; Microcavia australis/Carlos Soler/ www.flickr.com/ https://creativecommons.org/licenses/by/2.0/; Chinchilla lanigera/ Josh More/www.flickr.com/ https://creativecommons.org/licenses/by-nc-nd/2.0/; Ctenodactylus gundi/Chriest/www.flickr.com/ https://creativecommons.org/licenses/by-nc-sa/2.0/; Petromus typicus/ Jerry Oldenettel/ www.flickr.com/ https://creativecommons.org/licenses/by-nc-sa/2.0/; Octodon degus/stanhua/www.flickr.com/https://creativecommons.org/licenses/by/2.0/, This study was supported by the Ministry of Education, Science and Technological Development of the Republic of SerbiaGrant Number 451?03?68/2022?14/200007 and 451?03?68/2022?14/200114.

Funding Information:
This study was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia Grant Number 451–03–68/2022–14/200007 and 451–03–68/2022–14/200114 .

Publisher Copyright:
© 2022 The Committee on Space Research (COSPAR)

Keywords

  • Bone
  • Development
  • Mammal
  • Microgravity
  • Muscle
  • Reproduction

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