TY - JOUR
T1 - WHITE MATTER MICROSTRUCTURE AND AMYLOID AGGREGATION IN COGNITIVELY HEALTHY, ELDERLY IDENTICAL TWINS
AU - den Braber, Anouk
AU - Stickney, Kristine
AU - van 't Ent, Dennis
AU - ten Kate, Mara
AU - Konijnenberg, Elles
AU - Tomassen, Jori
AU - Barkhof, Frederik
AU - van Berckel, Bart N.M.
AU - Boomsma, Dorret I.
AU - de Geus, Eco
AU - Scheltens, Philip
AU - Visser, Pieter Jelle
N1 - First published: 01 July 2006.
PY - 2018/7
Y1 - 2018/7
N2 - Background: Lack of effective predictive models and/or treatments for Alzheimer's Disease (AD) has led a growing movement towards better characterization of pre-clinical stages. One currently established biomarker is positron emission tomography (PET) measured amyloid beta load. Here, in a genetically informative population of cognitively healthy, elderly identical twins, we compared this biomarker to a promising new candidate; white matter (WM) integrity measured by diffusion tensor imaging (DTI). Method(s): Eighty-eight genetically identical twin-pairs and 14 individual twins (n=190, mean age(SD)= 70 (7.5)) were selected from the EMIF-AD PreclinAD study. Abeta load, as a measure for amyloid aggregation, was quantified from [18F] Flutemetamol PET scans. Regional measurements of fractional anisotropy (FA) and mean diffusivity (MD), obtained with tract-based spatial statistics (TBSS) from FMRIB's Software Library (FSL), were used as measures for WM integrity. Within-subject associations between amyloid aggregation and WM integrity were estimated using generalized estimating equations, correcting for twin dependency. A possible shared etiology between amyloid aggregation and WM integrity was further explored using a cross-twin cross-trait (CTCT) design, testing whether amyloid aggregation in a twin could predict WM integrity in the co-twin. Analyses were adjusted for age, sex and intracranial volume. Result(s): Amyloid aggregation predicted trends in increased FA and decreased MD. Regions of interest (ROIs) that met p
AB - Background: Lack of effective predictive models and/or treatments for Alzheimer's Disease (AD) has led a growing movement towards better characterization of pre-clinical stages. One currently established biomarker is positron emission tomography (PET) measured amyloid beta load. Here, in a genetically informative population of cognitively healthy, elderly identical twins, we compared this biomarker to a promising new candidate; white matter (WM) integrity measured by diffusion tensor imaging (DTI). Method(s): Eighty-eight genetically identical twin-pairs and 14 individual twins (n=190, mean age(SD)= 70 (7.5)) were selected from the EMIF-AD PreclinAD study. Abeta load, as a measure for amyloid aggregation, was quantified from [18F] Flutemetamol PET scans. Regional measurements of fractional anisotropy (FA) and mean diffusivity (MD), obtained with tract-based spatial statistics (TBSS) from FMRIB's Software Library (FSL), were used as measures for WM integrity. Within-subject associations between amyloid aggregation and WM integrity were estimated using generalized estimating equations, correcting for twin dependency. A possible shared etiology between amyloid aggregation and WM integrity was further explored using a cross-twin cross-trait (CTCT) design, testing whether amyloid aggregation in a twin could predict WM integrity in the co-twin. Analyses were adjusted for age, sex and intracranial volume. Result(s): Amyloid aggregation predicted trends in increased FA and decreased MD. Regions of interest (ROIs) that met p
UR - https://www.mendeley.com/catalogue/32285a00-77b0-3798-a14d-58a6584ce345/
U2 - 10.1016/j.jalz.2018.06.427
DO - 10.1016/j.jalz.2018.06.427
M3 - Article
SN - 1552-5260
VL - 14
SP - P465-P465
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
IS - 7S Part 8
M1 - P1-418
ER -