Widefield SERS for High-Throughput Nanoparticle Screening

Matz Liebel; Irene Calderon; Nicolas Pazos-Perez; Niek F. van Hulst; Ramon A. Alvarez-Puebla

doi:10.1002/anie.202200072

Widefield SERS for High-Throughput Nanoparticle Screening

Matz Liebel, Irene Calderon, Nicolas Pazos-Perez, Niek F. van Hulst, Ramon A. Alvarez-Puebla

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Surface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of the full analytical potential of SERS. Here, we introduce large-scale SERS particle screening (LSSPS), a multiplexed widefield screening approach to particle characterization, which is 500–1000 times faster than typical confocal Raman implementations. Beyond its higher throughput, LSSPS simultaneously quantifies both the sample's Raman and Rayleigh scattering to directly quantify the fraction of SERS-active particles which allows for an unprecedented correlation of SERS activity with particle size.

Original language	English
Article number	e202200072
Journal	Angewandte Chemie - International Edition
Volume	61
Issue number	20
DOIs	https://doi.org/10.1002/anie.202200072
Publication status	Published - 9 May 2022
Externally published	Yes

Funding

M.L. and N.F.v.H. acknowledge support by the Ministry of Science, Innovation, and Universities (MCIU: RTI2018-099957-J-I00 and PGC2018-096875-B-I00). N.F.v.H. acknowledges the financial support by the European Commission (ERC Advanced Grant 670949-LightNet) and the Catalan AGAUR (2017SGR1369). This work was partially funded by CEX2019-000910-S [MCIN/ AEI/10.13039/501100011033], Fundació Privada Cellex, Fundació Privada Mir-Puig, and Generalitat de Catalunya through the CERCA program. I.C, N.P.P. and R.A.A.P. acknowledge support by the Ministry of Science, Innovation, and Universities/AEI (PID2020-120306RB-I00), Ministry of Science, Innovation, and Universities/ European Union Next Generation/PRTR (PDC2021-121787-I00), the Catalan AGAUR (2017SGR883), and the Universitat Rovira i Virgili (2021PFR-URV-B2-02). M.L. and N.F.v.H. acknowledge support by the Ministry of Science, Innovation, and Universities (MCIU: RTI2018‐099957‐J‐I00 and PGC2018‐096875‐B‐I00). N.F.v.H. acknowledges the financial support by the European Commission (ERC Advanced Grant 670949‐LightNet) and the Catalan AGAUR (2017SGR1369). This work was partially funded by CEX2019‐000910‐S [MCIN/ AEI/10.13039/501100011033], Fundació Privada Cellex, Fundació Privada Mir‐Puig, and Generalitat de Catalunya through the CERCA program. I.C, N.P.P. and R.A.A.P. acknowledge support by the Ministry of Science, Innovation, and Universities/AEI (PID2020‐120306RB‐I00), Ministry of Science, Innovation, and Universities/ European Union Next Generation/PRTR (PDC2021‐121787‐I00), the Catalan AGAUR (2017SGR883), and the Universitat Rovira i Virgili (2021PFR‐URV‐B2‐02).

Funders	Funder number
European Union Next Generation/PRTR	PDC2021‐121787‐I00, 2017SGR883
Fundació Privada Mir‐Puig
Fundación Cellex
Horizon 2020 Framework Programme	670949
Ministerio de Ciencia, Innovación y Universidades	RTI2018‐099957‐J‐I00, PGC2018‐096875‐B‐I00
European Commission
European Research Council
Generalitat de Catalunya	PID2020‐120306RB‐I00
Agència de Gestió d'Ajuts Universitaris i de Recerca	2017SGR1369, MCIN/ AEI/10.13039/501100011033
Ministerio de Ciencia e Innovación
Universitat Rovira i Virgili	2021PFR‐URV‐B2‐02
FUNDACIÓ Privada MIR-PUIG

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abstract = "Surface-enhanced Raman scattering (SERS) imaging is a powerful technology with unprecedent potential for ultrasensitive chemical analysis. Point-by-point scanning and often excessively long spectral acquisition-times hamper the broad exploitation of the full analytical potential of SERS. Here, we introduce large-scale SERS particle screening (LSSPS), a multiplexed widefield screening approach to particle characterization, which is 500–1000 times faster than typical confocal Raman implementations. Beyond its higher throughput, LSSPS simultaneously quantifies both the sample's Raman and Rayleigh scattering to directly quantify the fraction of SERS-active particles which allows for an unprecedented correlation of SERS activity with particle size.",

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Widefield SERS for High-Throughput Nanoparticle Screening

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