%PDF-1.4
%
1 0 obj
<<
/AcroForm 2 0 R
/Lang (EN)
/Metadata 3 0 R
/Names 4 0 R
/OpenAction <<
/D [5 0 R /FitV 2]
/S /GoTo
>>
/Outlines 6 0 R
/OutputIntents [7 0 R 8 0 R]
/PageLabels 9 0 R
/PageLayout /SinglePage
/PageMode /UseOutlines
/Pages 10 0 R
/Type /Catalog
/ViewerPreferences <<
/Direction /L2R
>>
>>
endobj
11 0 obj
<<
/Author (Philip R. Jansen)
/CreationDate (D:20190227104058+05'30')
/Creator (Springer)
/CrossMarkDomains#5B1#5D (springer.com)
/CrossMarkDomains#5B2#5D (springerlink.com)
/Keywords ()
/ModDate (D:20190227104154+05'30')
/Subject (Nature Genetics, doi:10.1038/s41588-018-0333-3)
/Title (Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways)
/doi (10.1038/s41588-018-0333-3)
>>
endobj
2 0 obj
<<
/DA (/Helv 0 Tf 0 g )
/DR <<
/Encoding <<
/PDFDocEncoding 12 0 R
>>
/Font <<
/Helv 13 0 R
/ZaDb 14 0 R
>>
>>
/Fields []
>>
endobj
3 0 obj
<<
/Length 31787
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
doi:10.1038/s41588-018-0333-3
Springer US
Nature Genetics, doi:10.1038/s41588-018-0333-3
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Philip R. Jansen
Kyoko Watanabe
Sven Stringer
Nathan Skene
Julien Bryois
Anke R. Hammerschlag
Christiaan A. de Leeuw
Jeroen S. Benjamins
Ana B. Muñoz-Manchado
Mats Nagel
Jeanne E. Savage
Henning Tiemeier
Tonya White
Michelle Agee
Babak Alipanahi
Adam Auton
Robert K. Bell
Katarzyna Bryc
Sarah L. Elson
Pierre Fontanillas
Nicholas A. Furlotte
David A. Hinds
Karen E. Huber
Aaron Kleinman
Nadia K. Litterman
Jennifer C. McCreight
Matthew H. McIntyre
Joanna L. Mountain
Elizabeth S. Noblin
Carrie A. M. Northover
Steven J. Pitts
J. Fah Sathirapongsasuti
Olga V. Sazonova
Janie F. Shelton
Suyash Shringarpure
Chao Tian
Catherine H. Wilson
Joyce Y. Tung
David A. Hinds
Vladimir Vacic
Xin Wang
Patrick F. Sullivan
Sophie van der Sluis
Tinca J. C. Polderman
August B. Smit
Jens Hjerling-Leffler
Eus J. W. Van Someren
Danielle Posthuma
10.1038/s41588-018-0333-3
http://dx.doi.org/10.1038/s41588-018-0333-3
journal
Nature Genetics
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
1546-1718
10.1038/s41588-018-0333-3
springer.com
springerlink.com
2010-04-23
True
10.1038/s41588-018-0333-3
springer.com
springerlink.com
Springer
2019-02-27T10:41:54+05:30
2019-02-27T10:40:58+05:30
2019-02-27T10:41:54+05:30
True
VoR
uuid:1aefeee6-0aa2-496a-8b92-82d66fd748dc
uuid:1997463f-6c15-4950-82d5-b4f70dcc450b
default
1
converted
uuid:72a55dae-3c37-43c8-ab7c-1ad993d64a50
converted to PDF/A-2b
pdfToolbox
2019-02-27T10:41:54+05:30
2
B
Philip R. Jansen
http://orcid.org/0000-0003-1550-2444
Kyoko Watanabe
http://orcid.org/0000-0002-3303-8860
Sven Stringer
http://orcid.org/0000-0003-3115-8532
Nathan Skene
http://orcid.org/0000-0002-6807-3180
Anke R. Hammerschlag
http://orcid.org/0000-0003-4847-4814
Christiaan A. de Leeuw
http://orcid.org/0000-0003-1076-9828
Jeroen S. Benjamins
http://orcid.org/0000-0003-4341-7167
Jeanne E. Savage
http://orcid.org/0000-0002-2034-8341
Henning Tiemeier
http://orcid.org/0000-0002-4395-1397
David A. Hinds
http://orcid.org/0000-0002-4911-803X
Tinca J. C. Polderman
http://orcid.org/0000-0001-5564-301X
Jens Hjerling-Leffler
http://orcid.org/0000-0002-4539-1776
Danielle Posthuma
http://orcid.org/0000-0001-7582-2365
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/pdfx/1.3/
pdfx
pdfx
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
Seq Text
internal
Mirrors crossmark:DOI
doi
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
http://crossref.org/crossmark/1.0/
crossmark
crossmark
internal
CrossMarkDomains
CrossMarkDomains
Seq Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was published.
MajorVersionDate
Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism
external
The aggregation type specifies the unit of aggregation for a content collection.
Comment
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element.
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Copyright
copyright
Text
external
The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only.
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs.
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn.
issn
Text
external
Title of the magazine, or other publication, in which a resource was/will be published.
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date.
Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
This element provides the url for an article or unit of content.
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element.
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
Text
http://springernature.com/ns/xmpExtensions/2.0/
sn
Springer Nature ORCID Schema
external
Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.
authorInfo
Bag AuthorInformation
Specifies the types of author information: name and ORCID of an author.
http://springernature.com/ns/xmpExtensions/2.0/authorInfo/
author
AuthorInformation
Gives the name of an author.
name
Text
Gives the ORCID of an author.
orcid
URI
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
4 0 obj
<<
/Dests 15 0 R
/EmbeddedFiles 16 0 R
>>
endobj
5 0 obj
<<
/Annots [17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R
27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R
37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R]
/ArtBox [0.0 0.0 595.276 790.866]
/BleedBox [0.0 0.0 595.276 790.866]
/Contents [47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R]
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 55 0 R
/Resources 56 0 R
/Rotate 0
/Thumb 57 0 R
/TrimBox [0.0 0.0 595.276 790.866]
/Type /Page
>>
endobj
6 0 obj
<<
/Count 16
/First 58 0 R
/Last 58 0 R
/Type /Outlines
>>
endobj
7 0 obj
<<
/DestOutputProfile 59 0 R
/Info (sRGB IEC61966-2.1)
/OutputCondition (sRGB)
/OutputConditionIdentifier (Custom)
/RegistryName ()
/S /GTS_PDFA1
/SpectralData <<
>>
/Type /OutputIntent
>>
endobj
8 0 obj
<<
/DestOutputProfile 59 0 R
/Info (sRGB IEC61966-2.1)
/OutputCondition (sRGB)
/OutputConditionIdentifier (Custom)
/RegistryName ()
/S /ISO_PDFE1
/SpectralData <<
>>
/Type /OutputIntent
>>
endobj
9 0 obj
<<
/Nums [0 60 0 R]
>>
endobj
10 0 obj
<<
/Count 16
/Kids [55 0 R 61 0 R]
/Type /Pages
>>
endobj
12 0 obj
<<
/Differences [24 /breve /caron /circumflex /dotaccent /hungarumlaut /ogonek /ring /tilde 39
/quotesingle 96 /grave 128 /bullet /dagger /daggerdbl /ellipsis /emdash /endash
/florin /fraction /guilsinglleft /guilsinglright /minus /perthousand /quotedblbase /quotedblleft /quotedblright /quoteleft
/quoteright /quotesinglbase /trademark /fi /fl /Lslash /OE /Scaron /Ydieresis /Zcaron
/dotlessi /lslash /oe /scaron /zcaron 160 /Euro 164 /currency 166
/brokenbar 168 /dieresis /copyright /ordfeminine 172 /logicalnot /.notdef /registered /macron
/degree /plusminus /twosuperior /threesuperior /acute /mu 183 /periodcentered /cedilla /onesuperior
/ordmasculine 188 /onequarter /onehalf /threequarters 192 /Agrave /Aacute /Acircumflex /Atilde
/Adieresis /Aring /AE /Ccedilla /Egrave /Eacute /Ecircumflex /Edieresis /Igrave /Iacute
/Icircumflex /Idieresis /Eth /Ntilde /Ograve /Oacute /Ocircumflex /Otilde /Odieresis /multiply
/Oslash /Ugrave /Uacute /Ucircumflex /Udieresis /Yacute /Thorn /germandbls /agrave /aacute
/acircumflex /atilde /adieresis /aring /ae /ccedilla /egrave /eacute /ecircumflex /edieresis
/igrave /iacute /icircumflex /idieresis /eth /ntilde /ograve /oacute /ocircumflex /otilde
/odieresis /divide /oslash /ugrave /uacute /ucircumflex /udieresis /yacute /thorn /ydieresis]
/Type /Encoding
>>
endobj
13 0 obj
<<
/BaseFont /Helvetica
/Encoding 12 0 R
/Name /Helv
/Subtype /Type1
/Type /Font
>>
endobj
14 0 obj
<<
/BaseFont /ZapfDingbats
/Name /ZaDb
/Subtype /Type1
/Type /Font
>>
endobj
15 0 obj
<<
/Kids [62 0 R 63 0 R 64 0 R]
>>
endobj
16 0 obj
<<
>>
endobj
17 0 obj
<<
/A 65 0 R
/AP <<
/N 66 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [240.005 54.7789 301.884 44.5389]
/Subtype /Link
/Type /Annot
>>
endobj
18 0 obj
<<
/AP <<
/N 67 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [247.265 359.707 249.868 347.161]
/Subtype /Link
/Type /Annot
>>
endobj
19 0 obj
<<
/AP <<
/N 68 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [183.073 338.707 185.675 326.161]
/Subtype /Link
/Type /Annot
>>
endobj
20 0 obj
<<
/AP <<
/N 69 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [218.78 307.207 221.382 294.661]
/Subtype /Link
/Type /Annot
>>
endobj
21 0 obj
<<
/AP <<
/N 70 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [249.382 296.707 251.985 284.161]
/Subtype /Link
/Type /Annot
>>
endobj
22 0 obj
<<
/AP <<
/N 71 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [237.432 275.707 240.035 263.161]
/Subtype /Link
/Type /Annot
>>
endobj
23 0 obj
<<
/AP <<
/N 72 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [283.672 265.207 286.275 252.661]
/Subtype /Link
/Type /Annot
>>
endobj
24 0 obj
<<
/AP <<
/N 73 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [103.44 234.321 106.042 220.278]
/Subtype /Link
/Type /Annot
>>
endobj
25 0 obj
<<
/AP <<
/N 74 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [107.278 234.321 109.881 220.278]
/Subtype /Link
/Type /Annot
>>
endobj
26 0 obj
<<
/AP <<
/N 75 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [546.315 359.828 548.917 347.161]
/Subtype /Link
/Type /Annot
>>
endobj
27 0 obj
<<
/AP <<
/N 76 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [550.153 359.828 552.756 347.161]
/Subtype /Link
/Type /Annot
>>
endobj
28 0 obj
<<
/AP <<
/N 77 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [429.118 349.207 431.721 336.661]
/Subtype /Link
/Type /Annot
>>
endobj
29 0 obj
<<
/AP <<
/N 78 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [550.153 296.707 552.756 284.161]
/Subtype /Link
/Type /Annot
>>
endobj
30 0 obj
<<
/AP <<
/N 79 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [393.755 276.321 398.96 262.278]
/Subtype /Link
/Type /Annot
>>
endobj
31 0 obj
<<
/AP <<
/N 80 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [400.196 276.321 405.401 262.278]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/AP <<
/N 81 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/Dest
/F 4
/H /N
/Rect [428.744 244.207 433.949 231.661]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/A 82 0 R
/AP <<
/N 83 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [119.655 595.784 128.491 580.292]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/A 84 0 R
/AP <<
/N 85 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [228.827 595.784 237.663 580.292]
/Subtype /Link
/Type /Annot
>>
endobj
35 0 obj
<<
/A 86 0 R
/AP <<
/N 87 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [314.206 595.784 323.042 580.292]
/Subtype /Link
/Type /Annot
>>
endobj
36 0 obj
<<
/A 88 0 R
/AP <<
/N 89 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [402.226 595.784 411.062 580.292]
/Subtype /Link
/Type /Annot
>>
endobj
37 0 obj
<<
/A 90 0 R
/AP <<
/N 91 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [159.41 579.784 168.246 564.292]
/Subtype /Link
/Type /Annot
>>
endobj
38 0 obj
<<
/A 92 0 R
/AP <<
/N 93 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [292.021 579.784 300.857 564.292]
/Subtype /Link
/Type /Annot
>>
endobj
39 0 obj
<<
/A 94 0 R
/AP <<
/N 95 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [409.368 579.784 418.204 564.292]
/Subtype /Link
/Type /Annot
>>
endobj
40 0 obj
<<
/A 96 0 R
/AP <<
/N 97 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [333.693 563.784 342.529 548.292]
/Subtype /Link
/Type /Annot
>>
endobj
41 0 obj
<<
/A 98 0 R
/AP <<
/N 99 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [441.825 563.784 450.661 548.292]
/Subtype /Link
/Type /Annot
>>
endobj
42 0 obj
<<
/A 100 0 R
/AP <<
/N 101 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [353.951 547.784 362.787 532.292]
/Subtype /Link
/Type /Annot
>>
endobj
43 0 obj
<<
/A 102 0 R
/AP <<
/N 103 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [373.267 531.784 382.103 516.292]
/Subtype /Link
/Type /Annot
>>
endobj
44 0 obj
<<
/A 104 0 R
/AP <<
/N 105 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [144.986 515.784 153.822 500.292]
/Subtype /Link
/Type /Annot
>>
endobj
45 0 obj
<<
/A 106 0 R
/AP <<
/N 107 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [416.125 515.784 424.961 500.292]
/Subtype /Link
/Type /Annot
>>
endobj
46 0 obj
<<
/A 108 0 R
/AP <<
/N 109 0 R
>>
/BS <<
/S /S
/Type /Border
/W 0
>>
/Border [0 0 0]
/F 4
/H /N
/Rect [460.514 33.864 552.756 25.1497]
/Subtype /Link
/Type /Annot
>>
endobj
47 0 obj
<<
/Length 1450
/Filter /FlateDecode
>>
stream
H[6)hdz-P Y^Jcŗ;e'!0mH}
k_Jzof ;
D?}H0,QPDc)HNQZe )Kc`Ѣ[!mVh*^пm Rw_G=m0g̘(F͈jɍ1TXvvll+eVEƘJ"~Ab':DT>E$oӬ